AI-guided discovery of the invariant host response to viral pandemics.

ABSTRACT:

Background

Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune response, a.k.a, the "cytokine storm" that has been implicated in fatal COVID-19 using an AI-based approach.

Method

Over 45,000 transcriptomic datasets of viral pandemics were analyzed to extract a 166-gene signature using ACE2 as a 'seed' gene; ACE2 was rationalized because it encodes the receptor that facilitates the entry of SARS-CoV-2 (the virus that causes COVID-19) into host cells. An AI-based approach was used to explore the utility of the signature in navigating the uncharted territory of Covid-19, setting therapeutic goals, and finding therapeutic solutions.

Findings

The 166-gene signature was su

SUBMITTER: Sahoo D 

PROVIDER: S-EPMC8193764 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature