Successful experimental infant baboon model for childhood cryptosporidiosis studies.

ABSTRACT:

Background

Cryptosporidiosis causes high morbidity and mortality in children under 2 years of age globally. The lack of an appropriate animal model that mimics the pathogenesis of disease in humans has hampered the development and testing of potential therapeutic options. This study aimed to develop and validate an infant baboon infection model of cryptosporidiosis.

Methods

Eighteen immunocompetent weaned infant baboons aged 12 to 16 months were used. The animals were n = 3 controls and three experimental groups of n = 5 animals each inoculated with Cryptosporidium parvum oocysts as follows: group 1: 2 × 10⁴, group 2: 2 × 10⁵, group 3: 2 × 10⁶ followed by daily fecal sampling for oocyst evaluation. Blood sampling for immunological assay was d

SUBMITTER: Jillani NE 

PROVIDER: S-EPMC8193905 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature