The role of RB1 alteration and 4q12 amplification in IDH-WT glioblastoma.

ABSTRACT:

Background

Recent studies have identified that glioblastoma IDH-wildtype (GBM IDH-WT) might be comprised of molecular subgroups with distinct prognoses. Therefore, we investigated the correlation between genetic alterations and survival in 282 GBM IDH-WT patients, to identify subgroups with distinct outcomes.

Methods

We reviewed characteristics of GBM IDH-WT (2009-2019) patients analyzed by next-generation sequencing interrogating 205 genes and 26 rearrangements. Progression-free survival (PFS) and overall survival (OS) were evaluated with the log-rank test and Cox regression models. We validated our results utilizing data from cBioPortal (MSK-IMPACT dataset).

Results

Multivariable analysis of GBM IDH-WT revealed that treatment with chemoradiation and RB1-mutan

SUBMITTER: Dono A 

PROVIDER: S-EPMC8193911 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature