Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies.

ABSTRACT: Cutaneous melanoma is an aggressive tumor responsible for 90% of mortality related to skin cancer. In the recent years, the discovery of driving mutations in melanoma has led to better treatment approaches. The last decade has seen a genomic revolution in the field of cancer. Such genomic revolution has led to the production of an unprecedented mole of data. High-throughput genomic technologies have facilitated the genomic, transcriptomic and epigenomic profiling of several cancers, including melanoma. Nevertheless, there are a number of newer genomic technologies that have not yet been employed in large studies. In this article we describe the current classification of cutaneous melanoma, we review the current knowledge of the main genetic alterations of cutaneous melanoma and their relat

SUBMITTER: Scatena C 

PROVIDER: S-EPMC8193952 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature