Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms.

ABSTRACT: The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and deubiquitylase activities, recognition of specific histone modifications, and interactions with transcription factors. Multiple lines of evidence indicate the existence of distinct variants of SAGA among organisms as well as within a species, permitting diverse functions to dynamically regulate cellular pathways. Our co-expression analysis of genes encoding human SAGA components showed enrichment in reproductive organs, brain tissues and the skeletal muscle, which corresponds to their established roles in developmental programs, emerging roles in neurodegenerative diseases, and understudied functions in specific cell types. SAGA subunits modul

SUBMITTER: Chen YC 

PROVIDER: S-EPMC8194025 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature