Downregulation of decidual SKP2 is associated with human recurrent miscarriage.

ABSTRACT:

Background

Recurrent miscarriage (RM) is a very frustrating problem for both couples and clinicians. To date, the etiology of RM remains poorly understood. Decidualization plays a critical role in implantation and the maintenance of pregnancy, and its deficiency is closely correlated with RM. The F-box protein S-phase kinase associated protein 2 (SKP2) is a key component of the SCF-type E3 ubiquitin ligase complex, which is critically involved in ErbB family-induced Akt ubiquitination, aerobic glycolysis and tumorigenesis. SKP2 is pivotal for reproduction, and SKP2-deficient mice show impaired ovarian development and reduced fertility.

Methods

Here, we investigated the expression and function of SKP2 in human decidualization and its relation with RM. A total of 40 decidual s

SUBMITTER: Lv S 

PROVIDER: S-EPMC8194034 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature