Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.

ABSTRACT: Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from Meis2 mutants and ChIPseq analy

SUBMITTER: Duran Alonso MB 

PROVIDER: S-EPMC8194062 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature