Altered neuropsychological performance and reduced brain volumetrics in people living with HIV on integrase strand transfer inhibitors.

ABSTRACT:

Objectives

Neuropsychiatric symptoms have been reported in people living with HIV (PLWH) on integrase strand transfer inhibitors (INSTIs) in postmarketing analysis. Limited data exist regarding brain integrity (function and structure) in PLWH prescribed INSTIs compared with other HIV treatment regimens.

Design

A cross-sectional analysis of PLWH on combined antiretroviral therapy aged more than 18 years at a single institution.

Methods

Neuropsychological tests were administered to calculate domain deficit scores in learning/memory, executive function and motor/psychomotor domains. Cortical and subcortical volumes from MRI were obtained using the FreeSurfer software suite (v5.3).

Results

Of 202 participants, median age 55 (48, 60) years old, 49% were on INSTI-bas

SUBMITTER: O'Halloran JA 

PROVIDER: S-EPMC8194092 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature