A theoretical framework for retrospective T2∗ correction to the arterial input function in quantitative myocardial perfusion MRI.

ABSTRACT:

Purpose

To develop and evaluate a flexible, Bloch-equation based framework for retrospective T2∗ correction to the arterial input function (AIF) obtained with quantitative cardiac perfusion pulse sequences.

Methods

Our framework initially calculates the gadolinium concentration [Gd] based on T₁ measurements alone. Next, T2∗ is estimated from this initial calculation of [Gd] while assuming fast water exchange and using the literature native T₂ and static magnetic field variation (ΔB₀ ) values. Finally, the [Gd] is recalculated after performing T2∗ correction to the Bloch equation signal model. Using this approach, we performed T2∗ correction to historical phantom and in vivo, dual-imaging perfusion data sets from 3 different patient groups obt

SUBMITTER: Fan L 

PROVIDER: S-EPMC8194096 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature