Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China.

ABSTRACT:

Background

Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in Gongcheng, southern China.

Methods

APOE rs405509 polymorphisms in 1724 participants (695 men and 1029 women, aged 45-97 years old) were genotyped using the Sequenom MassARRAY platform. Statistical analysis was conducted using SPSS 21.0 and Plink 1.90.

Results

The APOE rs405509 G allele was associated with lower hand grip strength in all participants (β = -1.04, P value <0.001), and the correlation seemed to be even stronger among women. A significant gene-environment interaction was observed betwee

SUBMITTER: He H 

PROVIDER: S-EPMC8194121 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature