Silicon dioxide nanoparticles induced neurobehavioral impairments by disrupting microbiota-gut-brain axis.

ABSTRACT:

Background

Silicon dioxide nanoparticles (SiO₂NPs) are widely used as additive in the food industry with controversial health risk. Gut microbiota is a new and hot topic in the field of nanotoxicity. It also contributes a novel and insightful view to understand the potential health risk of food-grade SiO₂NPs in children, who are susceptible to the toxic effects of nanoparticles.

Methods

In current study, the young mice were orally administrated with vehicle or SiO₂NPs solution for 28 days. The effects of SiO₂NPs on the gut microbiota were detected by 16S ribosomal RNA (rRNA) gene sequencing, and the neurobehavioral functions were evaluated by open field test and Morris water maze. The level of inflammation, tissue integrity of gut

SUBMITTER: Diao J 

PROVIDER: S-EPMC8194163 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature