Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.

ABSTRACT: Over the past few decades, an increasing variety of molecular chaperones have been investigated for their role in tumorigenesis and as potential chemotherapeutic targets; however, the 60 kDa Heat Shock Protein (HSP60), along with its HSP10 co-chaperone, have received little attention in this regard. In the present study, we investigated two series of our previously developed inhibitors of the bacterial homolog of HSP60/10, called GroEL/ES, for their selective cytotoxicity to cancerous over non-cancerous colorectal cells. We further developed a third "hybrid" series of analogs to identify new candidates with superior properties than the two parent scaffolds. Using a series of well-established HSP60/10 biochemical screens and cell-viability assays, we identified 24 inhibitors (14%) that exhi

SUBMITTER: Ray AM 

PROVIDER: S-EPMC8194340 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature