Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig.

ABSTRACT: The recent outbreaks of the Ebola virus (EBOV) in Africa have brought global visibility to the shortage of available therapeutic options to treat patients infected with this or closely related viruses. We have recently computationally identified three molecules which have all demonstrated statistically significant efficacy in the mouse model of infection with mouse adapted Ebola virus (ma-EBOV). One of these molecules is the antimalarial pyronaridine tetraphosphate (IC₅₀ range of 0.82-1.30 μM against three strains of EBOV and IC₅₀ range of 1.01-2.72 μM against two strains of Marburg virus (MARV)) which is an approved drug in the European Union and used in combination with artesunate. To date, no small molecule drugs have shown statistically significant efficacy in the

SUBMITTER: Lane TR 

PROVIDER: S-EPMC8194506 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature