Metabolomic Characterization of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).

ABSTRACT:

Introduction

PANS is a controversial clinical entity, consisting of a complex constellation of psychiatric symptoms, adventitious changes, and expression of various serological alterations, likely sustained by an autoimmune/inflammatory disease. Detection of novel biomarkers of PANS is highly desirable for both diagnostic and therapeutic management of affected patients. Analysis of metabolites has proven useful in detecting biomarkers for other neuroimmune-psychiatric diseases. Here, we utilize the metabolomics approach to determine whether it is possible to define a specific metabolic pattern in patients affected by PANS compared to healthy subjects.

Design

This observational case-control study tested consecutive patients referred for PANS between June 2019 to May 2020. A P

SUBMITTER: Murgia F 

PROVIDER: S-EPMC8194687 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature