A 3-day course of 1 mg/kg versus 2 mg/kg bodyweight prednisolone for 1- to 5-year-old children with acute moderate exacerbation of asthma: a randomized double-blind noninferiority trial.

ABSTRACT:

Background

Even though the guidelines on the management of preschool asthma recommend early use of corticosteroids for acute moderate-to-severe exacerbations, considerable variation exists with regard to type and dose of steroids.

Objectives

To compare the clinical outcomes and side effect profile between 1 mg/kg/day and 2 mg/kg/day of oral prednisolone when administered for 3 days in preschool children with acute moderate asthma exacerbations.

Study design and setting

Randomized double-blind noninferiority trial was done in the paediatric emergency of a teaching hospital.

Patients interventions and outcomes

A total of 128 children aged 1 to 5 years who presented to the paediatric emergency with acute moderate exacerbation of asthma were enrolled. They were ran

SUBMITTER: Buddala PK 

PROVIDER: S-EPMC8194769 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature