Systemic Characterization of Novel Immune Cell Phenotypes in Recurrent Pregnancy Loss.

ABSTRACT: Recurrent pregnancy loss (RPL) is a disturbing disease in women, and 50% of RPL is reported to be associated with immune dysfunction. Most previous studies of RPL focused mainly on the relationship between RPL and either T cells or natural killer (NK) cells in peripheral blood and the decidua; few studies presented the systemic profiles of the peripheral immune cell subsets in RPL women. Herein, we simultaneously detected 63 immune cell phenotypes in the peripheral blood from nonpregnant women (NPW), women with a history of normal pregnancy (NP) and women with a history of RPL (RPL) by multi-parameter flow cytometry. The results demonstrated that the percentages of naïve CD4⁺ T cells, central memory CD4⁺ T cells, naïve CD8⁺ T cells, mature NK cells, Vδ1

SUBMITTER: Liu H 

PROVIDER: S-EPMC8195235 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature