Dorsal Root Ganglion Stimulation Alleviates Pain-related Behaviors in Rats with Nerve Injury and Osteoarthritis.

ABSTRACT:

Background

Dorsal root ganglion field stimulation is an analgesic neuromodulation approach in use clinically, but its mechanism is unknown as there is no validated animal model for this purpose. The authors hypothesized that ganglion stimulation is effective in reducing pain-like behaviors in preclinical chronic pain models.

Methods

The authors provided ganglion stimulation or spinal cord stimulation to rats with traumatic neuropathy (tibial nerve injury), or osteoarthritis induced by intraarticular knee monosodium iodoacetate, or without injury (naïve). Analgesia was evaluated by testing a battery of pain-related reflexive, functional, and affective behaviors.

Results

In rats with nerve injury, multilevel L4 and L5 ganglion stimulation decreased hypersensitivity to n

SUBMITTER: Yu G 

PROVIDER: S-EPMC8195267 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature