Longitudinal Profiles of Dietary and Microbial Metabolites in Formula- and Breastfed Infants.

ABSTRACT: The early-life metabolome of the intestinal tract is dynamically influenced by colonization of gut microbiota which in turn is affected by nutrition, i.e. breast milk or formula. A detailed examination of fecal metabolites was performed to investigate the effect of probiotics in formula compared to control formula and breast milk within the first months of life in healthy neonates. A broad metabolomics approach was conceptualized to describe fecal polar and semi-polar metabolites affected by feeding type within the first year of life. Fecal metabolomes were clearly distinct between formula- and breastfed infants, mainly originating from diet and microbial metabolism. Unsaturated fatty acids and human milk oligosaccharides were increased in breastfed, whereas Maillard products were found in

SUBMITTER: Sillner N 

PROVIDER: S-EPMC8195334 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature