Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.

ABSTRACT:

Background

Huntington's disease (HD) is an inherited, progressive neurodegenerative disease that has no cure. Striatal atrophy and hypometabolism has been described in HD as far as 15 years before clinical onset and therefore structural and functional imaging biomarkers are the most applied biomarker modalities which call for these to be exact; however, most studies are not considering the partial volume effect and thereby tend to overestimate metabolic reductions, which may bias imaging outcome measures of interventions.

Objective

Evaluation of partial volume effects in a cohort of premanifest HD gene-expansion carriers (HDGECs).

Methods

21 HDGECs and 17 controls had a hybrid 2-[18F]FDG PET/MRI scan performed. Volume measurements and striatal metabolism, both correct

SUBMITTER: Hellem MNN 

PROVIDER: S-EPMC8195345 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature