Meningeal CGRP-Prolactin Interaction Evokes Female-Specific Migraine Behavior.

ABSTRACT:

Objective

Migraine is three times more common in women. CGRP plays a critical role in migraine pathology and causes female-specific behavioral responses upon meningeal application. These effects are likely mediated through interactions of CGRP with signaling systems specific to females. Prolactin (PRL) levels have been correlated with migraine attacks. Here, we explore a potential interaction between CGRP and PRL in the meninges.

Methods

Prolactin, CGRP, and receptor antagonists CGRP8-37 or Δ1-9-G129R-hPRL were administered onto the dura of rodents followed by behavioral testing. Immunohistochemistry was used to examine PRL, CGRP and Prolactin receptor (Prlr) expression within the dura. Electrophysiology on cultured and back-labeled trigeminal ganglia (TG) neurons was used t

SUBMITTER: Avona A 

PROVIDER: S-EPMC8195469 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature