Gut microbiome alpha-diversity is not a marker of Parkinson's disease and multiple sclerosis.

ABSTRACT: The gut-brain axis may play a central role in the pathogenesis of neurological disorders. Dozens of case-control studies have been carried out to identify bacterial markers by the use of targeted metagenomics. Alterations of several taxonomic profiles have been confirmed across several populations, however, no consensus has been made regarding alpha-diversity. A recent publication has described and validated a novel method based on richness and evenness measures of the gut microbiome in order to reduce the complexity and multiplicity of alpha-diversity indices. We used these recently described richness and evenness composite measures to investigate the potential link between gut microbiome alpha-diversity and neurological disorders and to determine to what extent it could be used as a mark

SUBMITTER: Plassais J 

PROVIDER: S-EPMC8195527 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature