Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.

ABSTRACT: Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and ZebrinII-negative cerebellar modules (Zhou et al., 2014; Wu et al., 2019). Here, we investigate the timing and extent of PC differentiation during development in mice. We found that several features of PCs, including activity levels, dendritic arborization, axonal shape and climbing fiber input, develop differentially between nodular and anterior PC populations. Although all PCs show a particularly rapid development in the second postnatal week, anterior PCs typically have a prolonged physiological and dendritic maturation. In line herewith, younger

SUBMITTER: Beekhof GC 

PROVIDER: S-EPMC8195607 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature