Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.

ABSTRACT: Aging of the nervous system is typified by depressed metabolism, compromised proteostasis, and increased inflammation that results in cognitive impairment. Differential expression analysis is a popular technique for exploring the molecular underpinnings of neural aging, but technical drawbacks of the methodology often obscure larger expression patterns. Co-expression analysis offers a robust alternative that allows for identification of networks of genes and their putative central regulators. In an effort to expand upon previous work exploring neural aging in the marine model Aplysia californica, we used weighted gene correlation network analysis to identify co-expression networks in a targeted set of aging sensory neurons in these animals. We identified twelve modules, six of which were s

SUBMITTER: Kron NS 

PROVIDER: S-EPMC8195618 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature