USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.

ABSTRACT: The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called "death-from-cancer" signature predicting therapy failure in cancer patients. However, the importance and functional role of USP22 in different types and subtypes of cancer remain largely unknown. In the present study, we leveraged human cell lines and genetic mouse models to investigate the role of USP22 in HER2-driven breast cancer (HER2⁺-BC) and demonstrate for the first time that USP22 is required for the tumorigenic properties in murine and human HER2⁺-BC models. To get insight into the underlying mechanisms, we performed transcriptome-wide gene expression analyses and identified the

SUBMITTER: Prokakis E 

PROVIDER: S-EPMC8195738 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature