Effects of central apneas on sympathovagal balance and hemodynamics at night: impact of underlying systolic heart failure.

ABSTRACT:

Background

Increased sympathetic drive is the key determinant of systolic heart failure progression, being associated with worse functional status, arrhythmias, and increased mortality. Central sleep apnea is highly prevalent in systolic heart failure, and its effects on sympathovagal balance (SVB) and hemodynamics might depend on relative phase duration and background pathophysiology.

Objective

This study compared the effects of central apneas in patients with and without systolic heart failure on SVB and hemodynamics during sleep.

Methods

During polysomnography, measures of SVB (heart rate and diastolic blood pressure variability) were non-invasively recorded and analyzed along with baroreceptor reflex sensitivity and hemodynamic parameters (stroke volume index, car

SUBMITTER: Spiesshoefer J 

PROVIDER: S-EPMC8195752 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature