CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma.

ABSTRACT:

Introduction

CD73 is a membrane-bound enzyme crucial in adenosine generation. The adenosinergic pathway plays a critical role in immunosuppression and in anti-tumor effects of immune checkpoint inhibitors (ICI). Here, we interrogated CD73 expression in a richly annotated cohort of human lung adenocarcinoma (LUAD) and its association with clinicopathological, immune, and molecular features to better understand the role of this immune marker in LUAD pathobiology.

Materials and methods

Protein expression of CD73 was evaluated by immunohistochemistry in 106 archived LUADs from patients that underwent surgical treatment without neoadjuvant therapy. Total CD73 (T +) was calculated as the average of luminal (L +) and basolateral (BL +) percentage membrane expression scores for each

SUBMITTER: Rocha P 

PROVIDER: S-EPMC8195808 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature