Estimates of the effects of physical activity on osteoporosis using multivariable Mendelian randomization analysis.

ABSTRACT: This study estimates causality of physical activity (PA) on bone mineral density (BMD) by conducting multivariable Mendelian randomization (MR). The findings suggest that habitual vigorous PA increases lumbar spine BMD, and higher overall acceleration average would improve forearm BMD. The results could promote PA intervention targeting individuals with optimized type.

Introduction

Evidence from epidemiologic studies showed type, frequency, and duration of PA influenced BMD. However, these observational studies may be confounded by many factors, resulting in spurious associations. We aimed to conduct multivariable MR to estimate the causal effect of self-reported and device-measured PA on osteoporosis.

Methods

Three self-reported and two device-measured PA-related traits were

SUBMITTER: Xu F 

PROVIDER: S-EPMC8195838 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature