Phase precession in the human hippocampus and entorhinal cortex.

ABSTRACT: Knowing where we are, where we have been, and where we are going is critical to many behaviors, including navigation and memory. One potential neuronal mechanism underlying this ability is phase precession, in which spatially tuned neurons represent sequences of positions by activating at progressively earlier phases of local network theta oscillations. Based on studies in rodents, researchers have hypothesized that phase precession may be a general neural pattern for representing sequential events for learning and memory. By recording human single-neuron activity during spatial navigation, we show that spatially tuned neurons in the human hippocampus and entorhinal cortex exhibit phase precession. Furthermore, beyond the neural representation of locations, we show evidence for phase prece

SUBMITTER: Qasim SE 

PROVIDER: S-EPMC8195854 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature