Placental gene networks at the interface between maternal PM_2.5 exposure early in gestation and reduced infant birthweight.

ABSTRACT:

Background

A growing body of evidence links maternal exposure to particulate matter <2.5 μM in diameter (PM_2.5) and deviations in fetal growth. Several studies suggest that the placenta plays a critical role in conveying the effects of maternal PM_2.5 exposure to the developing fetus. These include observed associations between air pollutants and candidate placental features, such as mitochondrial DNA content, DNA methylation and telomere length. However, gaps remain in delineating the pathways linking the placenta to air pollution-related health effects, including a comprehensive profiling of placental processes impacted by maternal PM_2.5 exposure. In this study, we examined alterations in a placental transcriptome-wide network in relation to matern

SUBMITTER: Deyssenroth MA 

PROVIDER: S-EPMC8195860 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature