Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice.
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ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC8195980 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice.
Zhou Yueying Y Xin Xiaonan X Wang Lichao L Wang Binsheng B Chen Li L Liu Ousheng O Rowe David W DW Xu Ming M
NPJ Regenerative medicine 20210611 1
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations. ...[more]
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