Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records.

ABSTRACT: Serosurveillance provides a unique opportunity to quantify the proportion of the population that has been exposed to pathogens. Here, we developed and piloted Serosurveillance for Continuous, ActionabLe Epidemiologic Intelligence of Transmission (SCALE-IT), a platform through which we systematically tested remnant samples from routine blood draws in two major hospital networks in San Francisco for SARS-CoV-2 antibodies during the early months of the pandemic. Importantly, SCALE-IT allows for algorithmic sample selection and rich data on covariates by leveraging electronic health record data. We estimated overall seroprevalence at 4.2%, corresponding to a case ascertainment rate of only 4.9%, and identified important heterogeneities by neighborhood, homelessness status, and race/ethnicity.

SUBMITTER: Routledge I 

PROVIDER: S-EPMC8195995 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature