Prenatal and childhood exposure to air pollution and traffic and the risk of liver injury in European children.

ABSTRACT: Nonalcoholic fatty liver disease is the most prevalent pediatric chronic liver disease. Experimental studies suggest effects of air pollution and traffic exposure on liver injury. We present the first large-scale human study to evaluate associations of prenatal and childhood air pollution and traffic exposure with liver injury.

Methods

Study population included 1,102 children from the Human Early Life Exposome project. Established liver injury biomarkers, including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, and cytokeratin-18, were measured in serum between ages 6-10 years. Air pollutant exposures included nitrogen dioxide, particulate matter <10 μm (PM₁₀), and <2.5 μm. Traffic measures included traffic density on nearest road, traff

SUBMITTER: Garcia E 

PROVIDER: S-EPMC8196121 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature