Antibody-dependent enhancement representing in vitro infective progeny virus titer correlates with the viremia level in dengue patients.

ABSTRACT: Dengue virus (DENV) causes dengue fever (DF) and dengue hemorrhagic fever in humans. Some DF patients suddenly develop severe symptoms around the defervescent period. Although the pathogenic mechanism of the severe symptoms has not been fully elucidated, the viremia level in the early phase has been shown to correlate with the disease severity. One of the hypotheses is that a phenomenon called antibody-dependent enhancement (ADE) of infection leads to high level of viremia. To examine the plausibility of this hypothesis, we examined the relationship between in vitro ADE activity and in vivo viral load quantity in six patients with dengue diseases. Blood samples were collected at multiple time points between the acute and defervescent phases, and the balance between neutralizing and enhanci

SUBMITTER: Yamanaka A 

PROVIDER: S-EPMC8196181 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature