Uncovering of cytochrome P450 anatomy by SecStrAnnotator.

ABSTRACT: Protein structural families are groups of homologous proteins defined by the organization of secondary structure elements (SSEs). Nowadays, many families contain vast numbers of structures, and the SSEs can help to orient within them. Communities around specific protein families have even developed specialized SSE annotations, always assigning the same name to the equivalent SSEs in homologous proteins. A detailed analysis of the groups of equivalent SSEs provides an overview of the studied family and enriches the analysis of any particular protein at hand. We developed a workflow for the analysis of the secondary structure anatomy of a protein family. We applied this analysis to the model family of cytochromes P450 (CYPs)-a family of important biotransformation enzymes with a community-wi

SUBMITTER: Midlik A 

PROVIDER: S-EPMC8196199 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature