Regional cerebral cholinergic nerve terminal integrity and cardinal motor features in Parkinson's disease.

ABSTRACT: Clinical effects of anti-cholinergic drugs implicate cholinergic systems alterations in the pathophysiology of some cardinal motor impairments in Parkinson's disease. The topography of affected cholinergic systems deficits and motor domain specificity are poorly understood. Parkinson's disease patients (n = 108) underwent clinical and motor assessment and vesicular acetylcholine transporter [¹⁸F]-fluoroethoxybenzovesamicol PET imaging. Volumes-of-interest-based analyses included detailed thalamic and cerebellar parcellations. Successful PET sampling for most of the small-sized parcellations was available in 88 patients. A data-driven approach, stepwise regression using the forward selection method, was used to identify cholinergic brain regions associating with cardinal d

SUBMITTER: Bohnen NI 

PROVIDER: S-EPMC8196256 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature