Tricyclic Antidepressant and/or γ-Aminobutyric Acid-Analog Use Is Associated With Fall Risk in Diabetic Peripheral Neuropathy.

ABSTRACT:

Background/objectives

Peripheral neuropathy is a common diabetes complication that can increase fall risk. Regarding fall risk, the impact of pain management using tricyclic antidepressants (TCAs) or γ-aminobutyric acid (GABA) analogs is unclear because these medications can also cause falls. This study investigates the impact of these drugs on fall and fracture risk in older diabetic peripheral neuropathy (DPN) patients.

Design

Historical cohort study with 1-to-1 propensity matching of TCA/GABA-analog users and nonusers.

Setting

Nationally representative 5% Medicare sample between the years 2008 and 2010.

Participants

After applying all selection criteria, 5,550 patients with prescription and 22,200 patients without prescription of TCAs/GABA-analogs were ident

SUBMITTER: Randolph AC 

PROVIDER: S-EPMC8196400 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature