Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets.

ABSTRACT:

Background

The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes. Therefore, the aim of this study was to determine the association between metabolic adaptation, at the level of resting metabolic rate (RMR), and weight and fat mass (FM) loss after low-energy diets (LED), after adjusting for dietary adherence and other confounders.

Methods

71 individuals with obesity (BMI: 34.6 ± 3.4 kg/m²; age: 45.4 ± 8.2 years; 33 males) were randomized to one of three 1000 kcal/day diets for 8 weeks. Body weight, FM and fat-free mass (FFM) (air displacement plethysmography), RMR (indirect calorimetry) and physical activity lev

SUBMITTER: Martins C 

PROVIDER: S-EPMC8196522 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature