The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-associated mortality in women. In particular, triple-negative BC (TNBC) has the highest rate of mortality due in large part to the lack of targeted treatment options for this subtype. Thus, there is an urgent need to identify new molecular targets for TNBC treatment. RALA and RALB are small GTPases implicated in growth and metastasis of a variety of cancers, although little is known of their roles in BC.

Methods

The necessity of RALA and RALB for TNBC tumor growth and metastasis were evaluated in vivo using orthotopic and tail-vein models. In vitro, 2D and 3D cell culture methods were used to evaluate the contributions of RALA and RALB during TNBC cell migration, invasion, and vi

SUBMITTER: Thies KA 

PROVIDER: S-EPMC8196523 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature