Identification of Hub Genes in Different Stages of Colorectal Cancer through an Integrated Bioinformatics Approach.

ABSTRACT: Colorectal cancer (CRC) is the third most common cancer that contributes to cancer-related morbidity. However, the differential expression of genes in different phases of CRC is largely unknown. Moreover, very little is known about the role of stress-survival pathways in CRC. We sought to discover the hub genes and identify their roles in several key pathways, including oxidative stress and apoptosis in the different stages of CRC. To identify the hub genes that may be involved in the different stages of CRC, gene expression datasets were obtained from the gene expression omnibus (GEO) database. The differentially expressed genes (DEGs) common among the different datasets for each group were obtained using the robust rank aggregation method. Then, gene enrichment analysis was carried out w

SUBMITTER: Patil AR 

PROVIDER: S-EPMC8197092 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature