Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells.

ABSTRACT: Breast cancer is the most frequently diagnosed malignant neoplasm and the second leading cause of cancer death among women. Epithelial-to-mesenchymal Transition (EMT) plays a critical role in the organism development, providing cell migration and tissue formation. However, its erroneous activation in malignancies can serve as the basis for the dissemination of cancer cells and metastasis. The Zeb1 transcription factor, which regulates the EMT activation, has been shown to play an essential role in malignant transformation. This factor is involved in many signaling pathways that influence a wide range of cellular functions via interacting with many proteins that affect its transcriptional functions. Importantly, the interactome of Zeb1 depends on the cellular context. Here, using the induci

SUBMITTER: Parfenyev SE 

PROVIDER: S-EPMC8197395 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature