AdipoRon and Other Adiponectin Receptor Agonists as Potential Candidates in Cancer Treatments.

ABSTRACT: The high mortality rate together with an ever-growing number of annual cases have defined neoplastic disorders as "the real 21st-century disease". Its dubious distinction also results from conventional therapy failure, which has made cancer an orphan disease. Therefore, innovative and alternative therapeutic strategies are mandatory. The ability to leverage human naturally occurring anti-tumor defenses has always represented a fascinating perspective, and the immuno blockage approval in cancer treatment represents in timeline the latest success. As a multifunctional organ, adipose tissue releases a large amount of adipokines having both carcinogenic and antitumor properties. The negative correlation between serum levels and risk for developing malignancies, as well as the huge number of ex

SUBMITTER: Nigro E 

PROVIDER: S-EPMC8197554 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature