Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic.

ABSTRACT: The methacholine challenge test is considered to be the gold standard bronchoprovocation test used to diagnose asthma, and this test is always performed in pulmonary function labs or doctors' offices. Methacholine (MCH) acts by inducing airway tightening/bronchoconstriction, and more importantly, MCH is hydrolyzed by cholinesterase enzyme (ChE). Recently, the American Thoracic Society raised concerns about pulmonary function testing during the COVID-19 pandemic due to recently reported correlation between cholinesterase and COVID-19 pneumonia severity/mortality, and it was shown that cholinesterase levels are reduced in the acute phase of severe COVID-19 pneumonia. This work describes the microfabrication of potentiometric sensors using copper as the substrate and chemically polymerized gr

SUBMITTER: ElDin NB 

PROVIDER: S-EPMC8197613 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature