Impact of GABA_A and GABA_B Inhibition on Cortical Dynamics and Perturbational Complexity during Synchronous and Desynchronized States.

ABSTRACT: Quantitative estimations of spatiotemporal complexity of cortical activity patterns are used in the clinic as a measure of consciousness levels, but the cortical mechanisms involved are not fully understood. We used a version of the perturbational complexity index (PCI) adapted to multisite recordings from the ferret (either sex) cerebral cortex in vitro (sPCI) to investigate the role of GABAergic inhibition in cortical complexity. We studied two dynamical states: slow-wave activity (synchronous state) and desynchronized activity, that express low and high causal complexity respectively. Progressive blockade of GABAergic inhibition during both regimes revealed its impact on the emergent cortical activity and on sPCI. Gradual GABA_A receptor blockade resulted in higher sync

SUBMITTER: Barbero-Castillo A 

PROVIDER: S-EPMC8197642 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature