O-GlcNAcylation Prediction: An Unattained Objective.

ABSTRACT:

Background

O-GlcNAcylation is an essential post-translational modification (PTM) in mammalian cells. It consists in the addition of a N-acetylglucosamine (GlcNAc) residue onto serines or threonines by an O-GlcNAc transferase (OGT). Inhibition of OGT is lethal, and misregulation of this PTM can lead to diverse pathologies including diabetes, Alzheimer's disease and cancers. Knowing the location of O-GlcNAcylation sites and the ability to accurately predict them is therefore of prime importance to a better understanding of this process and its related pathologies.

Purpose

Here, we present an evaluation of the current predictors of O-GlcNAcylation sites based on a newly built dataset and an investigation to improve predictions.

Methods

SUBMITTER: Mauri T 

PROVIDER: S-EPMC8197665 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature