GMP production of 6-[¹⁸F]Fluoro-L-DOPA for PET/CT imaging by different synthetic routes: a three center experience.

ABSTRACT:

Background

The radiofluorinated levodopa analogue 6-[¹⁸F]F-L-DOPA (3,4-dihydroxy-6-¹⁸F-L-phenylalanine) is a commonly employed radiotracer for PET/CT imaging of multiple oncological and neurological indications. An unusually large number of different radiosyntheses have been published to the point where two different Ph. Eur. monographs exist depending on whether the chemistry relies on electrophilic or nucleophilic radiosubstitution of appropriate chemical precursors. For new PET imaging sites wishing to adopt [¹⁸F]FDOPA into clinical practice, selecting the appropriate production process may be difficult and dependent on the clinical needs of the site.

Methods

Data from four years of [¹⁸F]FDOPA production at three different clini

SUBMITTER: Andersen VL 

PROVIDER: S-EPMC8197687 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature