Performance of nanoScan PET/CT and PET/MR for quantitative imaging of ¹⁸F and ⁸⁹Zr as compared with ex vivo biodistribution in tumor-bearing mice.

ABSTRACT:

Introduction

The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imaging allows for noninvasive longitudinal evaluation of tracer distribution in the same animals, but systemic comparison with ex vivo biodistribution is lacking. Our aim was to evaluate the potential of preclinical PET imaging for accurate tracer quantification, especially in tumor models.

Methods

NEMA NU 4-2008 phantoms were filled with ¹¹C, ⁶⁸Ga, ¹⁸F, or ⁸⁹Zr solutions and scanned in Mediso nanoPET/CT and PET/MR scanners until decay. N87 tumor-bearing mice were i.v. injected with either [¹⁸F]FDG (~ 14 MBq

SUBMITTER: Chomet M 

PROVIDER: S-EPMC8197690 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature