Admixture mapping identifies African and Amerindigenous local ancestry loci associated with fetal growth.

ABSTRACT: Fetal growth is an important determinant of cardiometabolic disease risk during childhood and adulthood. The genetic architecture of fetal growth remains largely understudied in ancestrally diverse populations. We conducted genome-wide admixture mapping scan and analysis of genetic ancestry among Hispanic American, African American, European American, and Asian American pregnant women to identify genetic loci associated with fetal growth measures across 13-40 weeks gestation. Fetal growth measures were associated with genome-wide average African, European, Amerindigenous and East Asian ancestry proportions (P ranged from10^-3 to 4.8 × 10^-2). Admixture mapping analysis identified ten African ancestry loci and three Amerindigenous ancestry loci significantly associated w

SUBMITTER: Tekola-Ayele F 

PROVIDER: S-EPMC8197736 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature