Modulation of motor cortical excitability by continuous theta-burst stimulation in adults with autism spectrum disorder.

ABSTRACT:

Objective

To test whether change in motor evoked potential (ΔMEP) induced by continuous theta-burst stimulation (cTBS) of motor cortex (M1) distinguishes adults with autism spectrum disorder (ASD) from neurotypicals, and to explore the contribution of two common polymorphisms related to neuroplasticity.

Methods

44 adult neurotypical (NT) participants (age 21-65, 34 males) and 19 adults with ASD (age 21-58, 17 males) prospectively underwent M1 cTBS. Their data were combined with previously obtained results from 35 NT and 35 ASD adults.

Results

ΔMEP at 15 minutes post-cTBS (T15) was a significant predictor of diagnosis (p = 0.04) in the present sample (n=63). T15 remained a significant predictor in a larger sample (n=91) and when partially imputed based on T10-T20 from

SUBMITTER: Jannati A 

PROVIDER: S-EPMC8197744 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature