BioFire^® FilmArray^® Pneumonia Panel for Severe Lower Respiratory Tract Infections: Subgroup Analysis of a Randomized Clinical Trial.

ABSTRACT:

Introduction

The epidemiology of severe lower respiratory tract infections (LRTI) is constantly changing. We aimed to describe it using the BioFire^® FilmArray^® Pneumonia plus (PNplus) Panel.

Methods

In a sub-study of the PROGRESS trial, sputum samples of 90 patients with sepsis and LRTI were retrospectively studied. The primary endpoint was the comparative detection rate of pathogens between conventional microbiology and PNplus Panel; secondary endpoints were microbiology and the association with the inflammatory host response.

Results

Fifty-six patients with community-acquired pneumonia without risk factors for multidrug-resistant (MDR) pathogens and another 34 patients with risk factors for MDR were studied; median pneumonia severity index (PSI

SUBMITTER: Kyriazopoulou E 

PROVIDER: S-EPMC8197784 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature