Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases.

ABSTRACT: Native biofluid peptides offer important information about diseases, holding promise as biomarkers. Particularly, the non-invasive nature of urine sampling, and its high peptide concentration, make urine peptidomics a useful strategy to study the pathogenesis of renal conditions. Moreover, the high number of detectable peptides as well as their specificity set the ground for the expansion of urine peptidomics to the identification of surrogate biomarkers for extra-renal diseases. Peptidomics further allows the prediction of proteases (degradomics), frequently dysregulated in disease, providing a complimentary source of information on disease pathogenesis and biomarkers. Then, what does urine peptidomics tell us so far? In this paper, we appraise the value of urine peptidomics in biomarker

SUBMITTER: Trindade F 

PROVIDER: S-EPMC8197949 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature